I got hooked on this comic in its web form when someone on an Evangelion mailing list forwarded a link to this. While Fred ‘Piro’ Gallagher’s Megatokyo is heavily influenced by dating sims/anime like Kanon, Air, Haibane Renmei, Michael Poe’s Exploitation Now has numerous references to Evangelion, tentacle monsters, ninjas and even one for Sailor Bubba.
I read the story as having two main threads. Initially it starts out like 4koma with a joke per comic centred on Bimbo Moneymaker (ex porn star) and Ralph Givememore (furry perv) who are gradually squeezed out by the narrative featuring Jordan Kennedy (teenage evil genius) and Bush Moneymaker (teenage deliquent turned evil genius right hand). The whole thing has a chaotic feel to it but somehow it all hangs together and manages to conclude rather well before the story really spun out of control.